|
KMID : 0605620230300010017
|
|
Journal of Korean Society of Biological Psychiatry
2023 Volume.30 No. 1 p.17 ~ p.23
|
|
|
Chronic Reserpine Administration for Depression Modeling in Zebrafish
|
|
Kim Se-Young
Han Chang-Su
Ko Young-Hoon
Kim Yong-Ku
Yoon Ho-Kyoung
Lee Jong-Ha
Kim Su-Hyun
Lee Chan-Hee
Shin Cheol-Min
|
|
|
Abstract
|
|
|
Objectives This study aims to develop valid experimental models for depression through chronic reserpine exposure to zebrafish (Danio rerio).
Methods The effect of chronic reserpine on zebrafish behavior in the novel tank was examined. Changes of gene expression on telencephalon were also investigated.
Results Chronic reserpine (40 mg/L, 7 days) induced overt behavioral effects, but markedly reduced activity, resembling motor retardation in depression. In telencephalon of zebrafish, gene expression associated with monoamine oxidase and norepinephrine transporter was decreased. Expression of serotonin transporter gene was increased.
Conclusions Our results show that the pharmacological model of depression in zebrafish can induce not only behavioral changes, but also monoamine changes in the homology of human mood regulation centers.
|
|
|
KEYWORD
|
|
|
Reserpine, Depression, Zebrafish, Animal model, Experimental model
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|